Functionalized carbon nanotubes9/13/2023 Consequently, the production of novel antibacterial agents or the application of innovative strategies to improve the pharmacokinetic and reduce resistance to available antibacterial drugs is of paramount importance.ĭiscovering new drugs is time-consuming and laborious. With no effective antibiotics, the medical world can once again return to the “pre-antibiotic era". The global crisis of antimicrobial resistance currently threatens both the effective prevention and treatment of a wide range of bacterial infectious diseases 3. However, inappropriate and excessive use of antibiotics caused the prevalence of antibiotic tolerance and resistance in the past decades 2. The introduction of antibiotics induced a radical decline in the rate of morbidity and mortality at the beginning of the twentieth century 1. Hence, MWCNTs can be considered a promising nano-carrier of LVX in the treatment of skin infections. The easy penetration to biological membranes and barriers can also increase the drug delivery at lower doses compared to the main drug alone, which can lead to the reduction of its side effects. In virtue of unique properties, MWCNTs can serve as a controlled release and delivery system for drugs. The nano-antibiotic has great industrialization potential for the simple route of synthesis, no toxicity, proper drug loading and release, low effective dose, and strong activity against wound infections. Based on the results, the antibacterial properties of the drug enhanced after conjugating with surface-modified MWCNTs. aureus wound infection model compared to LVX. The novel synthetic nano-drug possessed high loading capacity and pH-sensitive release profile resultantly, it exhibited very potent bactericidal activity in a mouse S. The noncytotoxic nano-antibiotic showed more satisfactory in vitro antibacterial activity against Staphylococcus aureus compared to Pseudomona aeruginosa. MWCNT-LVX was synthesized by a simple, reproducible and cost-effective method for the first time and characterized using various techniques, such as scanning electron microscope, transmission electron microscopy, and Brunauer–Emmett–Teller analysis, and so forth. The drug-loading and release profile at different pH levels was determined using an ultraviolet–visible spectrometer. This study is the first report on the evaluation of in vitro cell viability and antibacterial activity of nano-antibiotic along in addition to the in vivo antibacterial activity in a burn wound model. A new nano-antibiotic was synthesized from the conjugation of multi-walled carbon nanotubes with levofloxacin (MWCNT-LVX) through covalent grafting of drug with surface-modified carbon nanotubes in order to achieve an effective, safe, fast-acting nano-drug with the minimal side effects.
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